William Cain was born between 1760-1765, probably in Delaware. He, as a child, moved to Surry County, North Carolina where on 5 November 1801 he sold land his father, Thomas, had obtained by grant 29 September 1778. This land transaction was recorded in Surry County, North Carolina Deed Book 1 on pages 294 & 295. He married Hannah Stanfield around 1790. He bought and sold many pieces of property in Cumberland County, Kentucky before dying the 1830s. One is recorded in Deed Book D page 343.